Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies

The Tn antigen is a neoantigen abnormally expressed in many human carcinomas and expression correlates with metastasis and poor survival. To explore its biomarker potential, new antibodies are needed that specifically recognize this antigen in tumors. Here we generated two recombinant antibodies to...

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Detalhes bibliográficos
Publicado no:Glycobiology
Main Authors: Matsumoto, Yasuyuki, Kudelka, Matthew R, Hanes, Melinda S, Lehoux, Sylvain, Dutta, Sucharita, Jones, Mark B, Stackhouse, Kathryn A, Cervoni, Gabrielle E, Heimburg-Molinaro, Jamie, Smith, David F, Ju, Tongzhong, Chaikof, Elliot L, Cummings, Richard D
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175968/
https://ncbi.nlm.nih.gov/pubmed/31742337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwz095
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