Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins

The amyloid-like aggregation propensity present in most globular proteins is generally considered to be a secondary side effect resulting from the requirements of protein stability. Here, we demonstrate, however, that mutations in the globular and amyloid state are thermodynamically correlated rathe...

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Pubblicato in:Cell Rep
Autori principali: Langenberg, Tobias, Gallardo, Rodrigo, van der Kant, Rob, Louros, Nikolaos, Michiels, Emiel, Duran-Romaña, Ramon, Houben, Bert, Cassio, Rafaela, Wilkinson, Hannah, Garcia, Teresa, Ulens, Chris, Van Durme, Joost, Rousseau, Frederic, Schymkowitz, Joost
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175379/
https://ncbi.nlm.nih.gov/pubmed/32294448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.03.076
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