Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers. This gene silencing frequently occurs due to DNA methylation of the promoter regions, although the u...

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Publicat a:Biomolecules
Autors principals: Tramontano, Alfonso, Boffo, Francesca Ludovica, Russo, Giusi, De Rosa, Mariarosaria, Iodice, Ilaria, Pezone, Antonio
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175352/
https://ncbi.nlm.nih.gov/pubmed/32183138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10030446
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