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Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences
Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers. This gene silencing frequently occurs due to DNA methylation of the promoter regions, although the u...
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| Publié dans: | Biomolecules |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7175352/ https://ncbi.nlm.nih.gov/pubmed/32183138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10030446 |
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