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Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway
BACKGROUND AND PURPOSE: The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that target the PAG, their cellular actions...
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| Publicat a: | Br J Pharmacol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7174888/ https://ncbi.nlm.nih.gov/pubmed/31971607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14982 |
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