Circadian regulation of mitochondrial uncoupling and lifespan

Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in male Drosophila significantly extends lifespan. Th...

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Udgivet i:Nat Commun
Main Authors: Ulgherait, Matt, Chen, Anna, McAllister, Sophie F., Kim, Han X., Delventhal, Rebecca, Wayne, Charlotte R., Garcia, Christian J., Recinos, Yocelyn, Oliva, Miles, Canman, Julie C., Picard, Martin, Owusu-Ansah, Edward, Shirasu-Hiza, Mimi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174288/
https://ncbi.nlm.nih.gov/pubmed/32317636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15617-x
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