Circadian regulation of mitochondrial uncoupling and lifespan

Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in male Drosophila significantly extends lifespan. Th...

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Publicat a:Nat Commun
Autors principals: Ulgherait, Matt, Chen, Anna, McAllister, Sophie F., Kim, Han X., Delventhal, Rebecca, Wayne, Charlotte R., Garcia, Christian J., Recinos, Yocelyn, Oliva, Miles, Canman, Julie C., Picard, Martin, Owusu-Ansah, Edward, Shirasu-Hiza, Mimi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174288/
https://ncbi.nlm.nih.gov/pubmed/32317636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15617-x
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