Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

In Drosophila, ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these neurons secrete the neuropeptide Pdf and have been called ‘master pacemakers’ because they are essential for circadian rhythms. A subset of Pdf(+) neurons (the morning oscillator) regulates...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Delventhal, Rebecca, O'Connor, Reed M, Pantalia, Meghan M, Ulgherait, Matthew, Kim, Han X, Basturk, Maylis K, Canman, Julie C, Shirasu-Hiza, Mimi
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794090/
https://ncbi.nlm.nih.gov/pubmed/31613218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48308
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