Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers

Robust transport of therapeutic peptides and other medicinal molecules across tight epithelial barriers would overcome the major obstacle to oral delivery. We have already demonstrated that peptides conjugated to gangliosides (GM1 and GM3) having non-native short N-acyl groups hijack the endogenous...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Main Authors: Duclos, Richard I., Blue, Kiara D., Rufo, Michael J., Chen, Xiaoling, Guo, Jason J., Ma, Xiaoyu, Lencer, Wayne I., Chinnapen, Daniel J.-F.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174066/
https://ncbi.nlm.nih.gov/pubmed/32081448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127014
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares