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Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers
Robust transport of therapeutic peptides and other medicinal molecules across tight epithelial barriers would overcome the major obstacle to oral delivery. We have already demonstrated that peptides conjugated to gangliosides (GM1 and GM3) having non-native short N-acyl groups hijack the endogenous...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7174066/ https://ncbi.nlm.nih.gov/pubmed/32081448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127014 |
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