Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers

Robust transport of therapeutic peptides and other medicinal molecules across tight epithelial barriers would overcome the major obstacle to oral delivery. We have already demonstrated that peptides conjugated to gangliosides (GM1 and GM3) having non-native short N-acyl groups hijack the endogenous...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem Lett
Huvudupphovsmän: Duclos, Richard I., Blue, Kiara D., Rufo, Michael J., Chen, Xiaoling, Guo, Jason J., Ma, Xiaoyu, Lencer, Wayne I., Chinnapen, Daniel J.-F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174066/
https://ncbi.nlm.nih.gov/pubmed/32081448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127014
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