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Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity

Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrical voltage across the channel, and proton concentra...

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Foilsithe in:PLoS Comput Biol
Main Authors: Lee, Juhwan, Kang, Mooseok, Kim, Sangyeol, Chang, Iksoo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7173763/
https://ncbi.nlm.nih.gov/pubmed/32315300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007405
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