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Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity

Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrical voltage across the channel, and proton concentra...

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Publicat a:PLoS Comput Biol
Autors principals: Lee, Juhwan, Kang, Mooseok, Kim, Sangyeol, Chang, Iksoo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7173763/
https://ncbi.nlm.nih.gov/pubmed/32315300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007405
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