The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease

The spirochete Borrelia burgdorferi sensu lato is the causative agent of Lyme disease (LD). The spirochetes produce the CspZ protein that binds to a complement regulator, factor H (FH). Such binding downregulates activation of host complement to facilitate spirochete evasion of complement killing. H...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Marcinkiewicz, Ashley L., Lieknina, Ilva, Yang, Xiuli, Lederman, Patricia L., Hart, Thomas M., Yates, Jennifer, Chen, Wen-Hsiang, Bottazzi, Maria Elena, Mantis, Nicholas J., Kraiczy, Peter, Pal, Utpal, Tars, Kaspars, Lin, Yi-Pin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171238/
https://ncbi.nlm.nih.gov/pubmed/32122944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00956-19
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