The MicroRNA MiR-29c Alleviates Renal Fibrosis via TPM1-Mediated Suppression of the Wnt/β-Catenin Pathway

PURPOSE: This study aimed to evaluate the mechanism by which miR-29c expression in fibroblasts regulates renal interstitial fibrosis. METHODS: We stimulated NRK-49F cells with TGF-β1 to mimic the effects of fibrosis in vitro, while unilateral ureteral obstruction (UUO) was performed to obstruct the...

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Pubblicato in:Front Physiol
Autori principali: Huang, Huiya, Huang, Xiaozhong, Luo, Shengnan, Zhang, Huidi, Hu, Feifei, Chen, Ruyi, Huang, Chaoxing, Su, Zhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171049/
https://ncbi.nlm.nih.gov/pubmed/32346368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00331
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