High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange

Peptide exchange technologies are essential for the generation of pMHC-multimer libraries used to probe diverse, polyclonal TCR repertoires in various settings. Here, using the molecular chaperone TAPBPR, we develop a robust method for the capture of stable, empty MHC-I molecules comprising murine H...

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Publicado no:Nat Commun
Main Authors: Overall, Sarah A., Toor, Jugmohit S., Hao, Stephanie, Yarmarkovich, Mark, Sara M. O’Rourke, Morozov, Giora I., Nguyen, Son, Japp, Alberto Sada, Gonzalez, Nicolas, Moschidi, Danai, Betts, Michael R., Maris, John M., Smibert, Peter, Sgourakis, Nikolaos G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170893/
https://ncbi.nlm.nih.gov/pubmed/32312993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15710-1
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