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Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways

The adaptation of mitochondrial homeostasis to ischemic injury is not fully understood. Here, we studied the role of dynamin-related protein 1 (Drp1) in this process. We found that mitochondrial morphology was altered in the early stage of ischemic injury while mitochondrial dysfunction occurred in...

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Vydáno v:Cell Death Dis
Hlavní autoři: Duan, Chenyang, Kuang, Lei, Xiang, Xinming, Zhang, Jie, Zhu, Yu, Wu, Yue, Yan, Qingguang, Liu, Liangming, Li, Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170874/
https://ncbi.nlm.nih.gov/pubmed/32312970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2461-9
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