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Perturbing proteomes at single residue resolution using base editing

Base editors derived from CRISPR-Cas9 systems and DNA editing enzymes offer an unprecedented opportunity for the precise modification of genes, but have yet to be used at a genome-scale throughput. Here, we test the ability of the Target-AID base editor to systematically modify genes genome-wide by...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Després, Philippe C., Dubé, Alexandre K., Seki, Motoaki, Yachie, Nozomu, Landry, Christian R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170841/
https://ncbi.nlm.nih.gov/pubmed/32313011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15796-7
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