γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Hypersecretion of glucagon from pancreatic α-cells strongly contributes to diabetic hyperglycemia. Moreover, failure of α-cells to increase glucagon secretion in response to falling blood glucose concentrations compromises the defense against hypoglycemia, a common complication in diabetes therapy....

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Yu, Qian, Lai, Bao Khanh, Ahooghalandari, Parvin, Helander, Anders, Gylfe, Erik, Gilon, Patrick, Tengholm, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170508/
https://ncbi.nlm.nih.gov/pubmed/32156704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009577
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