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Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)(3) template mediated strategy

Three-stranded coiled coils are peptide structures constructed from amphipathic heptad repeats. Here we show that it is possible to form pure heterotrimeric three-stranded coiled coils by combining three distinct characteristics: (1) a cysteine sulfur layer for metal coordination, (2) a thiophilic,...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Tolbert, Audrey E., Ervin, Catherine S., Ruckthong, Leela, Paul, Thomas J., Jayasinghe-Arachchige, Vindi M., Neupane, Kosh P., Stuckey, Jeanne A., Prabhakar, Rajeev, Pecoraro, Vincent L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7169047/
https://ncbi.nlm.nih.gov/pubmed/32123337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-020-0423-6
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