Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca(2+)-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

B-cell activating factor (BAFF) is a crucial survival factor for B cells, and excess BAFF contributes to development of autoimmune diseases. Recent studies have shown that rapamycin can prevent BAFF-induced B-cell proliferation and survival, but the underlying mechanism remains to be elucidated. Her...

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Veröffentlicht in:Cell Calcium
Hauptverfasser: Zeng, Qingyu, Zhou, Zhihan, Qin, Shanshan, Yao, Yajie, Qin, Jiamin, Zhang, Hai, Zhang, Ruijie, Xu, Chong, Zhang, Shuangquan, Huang, Shile, Chen, Long
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7168758/
https://ncbi.nlm.nih.gov/pubmed/32062191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2020.102171
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