Family Study Designs to Combat Heterogeneity and Identify Multi-Cancer Pleiotropies: The Power of the Utah Population Database

BACKGROUND: Previously, family-based designs and high-risk pedigrees have illustrated value for the discovery of high- and intermediate-risk germline breast cancer susceptibility genes. However, genetic heterogeneity is a major obstacle hindering progress. New strategies and analytic approaches will...

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Detalhes bibliográficos
Publicado no:Cancer Epidemiol Biomarkers Prev
Main Authors: Hanson, Heidi A., Leiser, Claire L., Madsen, Michael J., Gardner, John, Knight, Stacey, Cessna, Melissa, Sweeney, Carol, Doherty, Jennifer A., Smith, Ken R., Bernard, Philip S., Camp, Nicola J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7168701/
https://ncbi.nlm.nih.gov/pubmed/32098891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-19-0912
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