Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a major outbreak of respiratory disease centered on Hubei province, China. It is now a global pandemic and is a major public health concern. Taxonomically, SARS-CoV-2 was shown to be a Betacoronavirus (lineage B) closely r...

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Publicado en:J Mol Biol
Autores principales: Jaimes, Javier A., André, Nicole M., Chappie, Joshua S., Millet, Jean K., Whittaker, Gary R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Ltd. 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166309/
https://ncbi.nlm.nih.gov/pubmed/32320687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.04.009
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