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Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses

The 2019 novel coronavirus (2019-nCoV) is currently causing a widespread outbreak centered on Hubei province, China and is a major public health concern. Taxonomically 2019-nCoV is closely related to SARS-CoV and SARS-related bat coronaviruses, and it appears to share a common receptor with SARS-CoV...

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Bibliographische Detailangaben
Veröffentlicht in:bioRxiv
Hauptverfasser: Jaimes, Javier A., André, Nicole M., Millet, Jean K., Whittaker, Gary R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217298/
https://ncbi.nlm.nih.gov/pubmed/32511311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.02.10.942185
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