A high–throughput digital script for multiplexed immunofluorescent analysis and quantification of sarcolemmal and sarcomeric proteins in muscular dystrophies

The primary molecular endpoint for many Duchenne muscular dystrophy (DMD) clinical trials is the induction, or increase in production, of dystrophin protein in striated muscle. For accurate endpoint analysis, it is essential to have reliable, robust and objective quantification methodologies capable...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Scaglioni, Dominic, Ellis, Matthew, Catapano, Francesco, Torelli, Silvia, Chambers, Darren, Feng, Lucy, Sewry, Caroline, Morgan, Jennifer, Muntoni, Francesco, Phadke, Rahul
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165405/
https://ncbi.nlm.nih.gov/pubmed/32303261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00918-5
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