A high–throughput digital script for multiplexed immunofluorescent analysis and quantification of sarcolemmal and sarcomeric proteins in muscular dystrophies

The primary molecular endpoint for many Duchenne muscular dystrophy (DMD) clinical trials is the induction, or increase in production, of dystrophin protein in striated muscle. For accurate endpoint analysis, it is essential to have reliable, robust and objective quantification methodologies capable...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Scaglioni, Dominic, Ellis, Matthew, Catapano, Francesco, Torelli, Silvia, Chambers, Darren, Feng, Lucy, Sewry, Caroline, Morgan, Jennifer, Muntoni, Francesco, Phadke, Rahul
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165405/
https://ncbi.nlm.nih.gov/pubmed/32303261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00918-5
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