Simultaneous detection of EGFR amplification and EGFRvIII variant using digital PCR-based method in glioblastoma

Epidermal growth factor receptor (EGFR) amplification and EGFR variant III (EGFRvIII, deletion of exons 2–7) are of clinical interest for glioblastoma. The aim was to develop a digital PCR (dPCR)-based method using locked nucleic acid (LNA)-based hydrolysis probes, allowing the simultaneous detectio...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Fontanilles, Maxime, Marguet, Florent, Ruminy, Philippe, Basset, Carole, Noel, Adrien, Beaussire, Ludivine, Viennot, Mathieu, Viailly, Pierre-Julien, Cassinari, Kevin, Chambon, Pascal, Richard, Doriane, Alexandru, Cristina, Tennevet, Isabelle, Langlois, Olivier, Di Fiore, Frédéric, Laquerrière, Annie, Clatot, Florian, Sarafan-Vasseur, Nasrin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165387/
https://ncbi.nlm.nih.gov/pubmed/32303258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00917-6
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