Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and effectively improve enzyme stability are highly appealing. In this study we applied a computational method (FRESCO) to guide the engineering of an alcohol dehydrogenase....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Aalbers, Friso S, Fürst, Maximilian JLJ, Rovida, Stefano, Trajkovic, Milos, Gómez Castellanos, J Rubén, Bartsch, Sebastian, Vogel, Andreas, Mattevi, Andrea, Fraaije, Marco W
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Computational and Systems Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164962/
https://ncbi.nlm.nih.gov/pubmed/32228861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54639
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