Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

Chemotaxis of fibroblasts and other mesenchymal cells is critical for embryonic development and wound healing. Fibroblast chemotaxis directed by a gradient of platelet-derived growth factor (PDGF) requires signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway. Diacylglycerol (DA...

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Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Nosbisch, Jamie L., Rahman, Anisur, Mohan, Krithika, Elston, Timothy C., Bear, James E., Haugh, Jason M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164671/
https://ncbi.nlm.nih.gov/pubmed/32255775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007708
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