Genetic variation in EPHA contributes to sensitivity to paclitaxel‐induced peripheral neuropathy

AIMS: Chemotherapy‐induced peripheral neuropathy (PN) is a treatment limiting toxicity of paclitaxel. We evaluated if EPHA genetic variation (EPHA4, EPHA5, EPHA6, and EPHA8) is associated with PN sensitivity by accounting for variability in systemic paclitaxel exposure (time above threshold). METHOD...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Marcath, Lauren A., Kidwell, Kelley M., Vangipuram, Kiran, Gersch, Christina L., Rae, James M., Burness, Monika L., Griggs, Jennifer J., Van Poznak, Catherine, Hayes, Daniel F., Smith, Ellen M. Lavoie, Henry, N. Lynn, Beutler, Andreas S., Hertz, Daniel L.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163383/
https://ncbi.nlm.nih.gov/pubmed/31823378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14192
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