Genetic variation in EPHA contributes to sensitivity to paclitaxel‐induced peripheral neuropathy

AIMS: Chemotherapy‐induced peripheral neuropathy (PN) is a treatment limiting toxicity of paclitaxel. We evaluated if EPHA genetic variation (EPHA4, EPHA5, EPHA6, and EPHA8) is associated with PN sensitivity by accounting for variability in systemic paclitaxel exposure (time above threshold). METHOD...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Br J Clin Pharmacol
Auteurs principaux: Marcath, Lauren A., Kidwell, Kelley M., Vangipuram, Kiran, Gersch, Christina L., Rae, James M., Burness, Monika L., Griggs, Jennifer J., Van Poznak, Catherine, Hayes, Daniel F., Smith, Ellen M. Lavoie, Henry, N. Lynn, Beutler, Andreas S., Hertz, Daniel L.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163383/
https://ncbi.nlm.nih.gov/pubmed/31823378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14192
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires