Genetic variation in EPHA contributes to sensitivity to paclitaxel‐induced peripheral neuropathy

AIMS: Chemotherapy‐induced peripheral neuropathy (PN) is a treatment limiting toxicity of paclitaxel. We evaluated if EPHA genetic variation (EPHA4, EPHA5, EPHA6, and EPHA8) is associated with PN sensitivity by accounting for variability in systemic paclitaxel exposure (time above threshold). METHOD...

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Publicado en:Br J Clin Pharmacol
Autores principales: Marcath, Lauren A., Kidwell, Kelley M., Vangipuram, Kiran, Gersch, Christina L., Rae, James M., Burness, Monika L., Griggs, Jennifer J., Van Poznak, Catherine, Hayes, Daniel F., Smith, Ellen M. Lavoie, Henry, N. Lynn, Beutler, Andreas S., Hertz, Daniel L.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163383/
https://ncbi.nlm.nih.gov/pubmed/31823378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14192
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