A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The VaSera trial testing dietary nitrate and spironolactone

AIMS: To test if spironolactone or dietary nitrate from beetroot juice could reduce arterial stiffness as aortic pulse wave velocity (PWVart), a potential treatment target, independently of blood pressure. METHODS: Daily spironolactone (≤50 mg) vs doxazosin (control ≤16 mg) and 70 mL beetroot juice...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Mills, Charlotte E., Govoni, Virginia, Faconti, Luca, Casagrande, Maria‐Linda, Morant, Steven V., Crickmore, Hannah, Iqbal, Fahad, Maskell, Perry, Masani, Alisha, Nanino, Elisa, Webb, Andrew J., Cruickshank, J. Kennedy
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163378/
https://ncbi.nlm.nih.gov/pubmed/31833569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14194
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