Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontaneously develop steatosis without obesity in aging. St...

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Publicado no:Sci Rep
Main Authors: Régnier, Marion, Polizzi, Arnaud, Smati, Sarra, Lukowicz, Céline, Fougerat, Anne, Lippi, Yannick, Fouché, Edwin, Lasserre, Frédéric, Naylies, Claire, Bétoulières, Colette, Barquissau, Valentin, Mouisel, Etienne, Bertrand-Michel, Justine, Batut, Aurélie, Saati, Talal Al, Canlet, Cécile, Tremblay-Franco, Marie, Ellero-Simatos, Sandrine, Langin, Dominique, Postic, Catherine, Wahli, Walter, Loiseau, Nicolas, Guillou, Hervé, Montagner, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162950/
https://ncbi.nlm.nih.gov/pubmed/32300166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63579-3
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