Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

OBJECTIVE: Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role in metabolism. In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD). DESIGN: We const...

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Pubblicato in:Gut
Autori principali: Montagner, Alexandra, Polizzi, Arnaud, Fouché, Edwin, Ducheix, Simon, Lippi, Yannick, Lasserre, Frédéric, Barquissau, Valentin, Régnier, Marion, Lukowicz, Céline, Benhamed, Fadila, Iroz, Alison, Bertrand-Michel, Justine, Al Saati, Talal, Cano, Patricia, Mselli-Lakhal, Laila, Mithieux, Gilles, Rajas, Fabienne, Lagarrigue, Sandrine, Pineau, Thierry, Loiseau, Nicolas, Postic, Catherine, Langin, Dominique, Wahli, Walter, Guillou, Hervé
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2016
Soggetti:
Hepatology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941147/
https://ncbi.nlm.nih.gov/pubmed/26838599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310798
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