Melatonin up‐regulates bone marrow mesenchymal stem cells osteogenic action but suppresses their mediated osteoclastogenesis via MT(2)‐inactivated NF‐κB pathway

BACKGROUND AND PURPOSE: Melatonin is a neurohormone involved in bone homeostasis. Melatonin directs bone remodelling and the role of bone marrow mesenchymal stem cells (BMMSCs) in the regulating melatonin‐mediated bone formation–resorption balance remains undefined. EXPERIMENTAL APPROACH: Osteoporos...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Zhou, Yi, Wang, Chaowei, Si, Jinyan, Wang, Baixiang, Zhang, Denghui, Ding, Ding, Zhang, Jian, Wang, Huiming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161576/
https://ncbi.nlm.nih.gov/pubmed/31900938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14972
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