Characterizing Interhelical Interactions of G-Protein Coupled Receptors with the Fragment Molecular Orbital Method

[Image: see text] G-protein coupled receptors (GPCRs) are the largest superfamily of membrane proteins, regulating almost every aspect of cellular activity and serving as key targets for drug discovery. We have identified an accurate and reliable computational method to characterize the strength and...

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Xehetasun bibliografikoak
Argitaratua izan da:J Chem Theory Comput
Egile Nagusiak: Heifetz, Alexander, Morao, Inaki, Babu, M. Madan, James, Tim, Southey, Michelle W. Y., Fedorov, Dmitri G., Aldeghi, Matteo, Bodkin, Michael J., Townsend-Nicholson, Andrea
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2020
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161079/
https://ncbi.nlm.nih.gov/pubmed/32096994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.9b01136
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