S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tested the hypothesis that this protection is not due to a red...

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Udgivet i:Cell Rep
Main Authors: Cohen, Taylor S., Boland, Michelle L., Boland, Brandon B., Takahashi, Virginia, Tovchigrechko, Andrey, Lee, Young, Wilde, Aimee D., Mazaitis, Mark J., Jones-Nelson, Omari, Tkaczyk, Christine, Raja, Rajiv, Stover, C. Kendall, Sellman, Bret R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160668/
https://ncbi.nlm.nih.gov/pubmed/29490278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.027
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