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Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4

Matrix Gla protein (MGP), a modulator of the BMP-SMAD signals, inhibits arterial calcification in a Glu γ-carboxylation dependent manner but the role of MGP highly expressed in a subset of bone marrow (BM) mesenchymal stem/stromal cells is unknown. Here we provide evidence that MGP might be a niche...

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Veröffentlicht in:Heliyon
Hauptverfasser: Kuronuma, Kana, Yokoi, Aya, Fukuoka, Tomoya, Miyata, Muneaki, Maekawa, Akio, Tanaka, Satowa, Matsubara, Leo, Goto, Chie, Matsuo, Miki, Han, Hao-Wei, Tsuruta, Mai, Murata, Haruka, Okamoto, Hikari, Hasegawa, Natsumi, Asano, Shigetaka, Ito, Mitsuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160454/
https://ncbi.nlm.nih.gov/pubmed/32322728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e03743
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