A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision

Studies on multisite phosphorylation networks of cyclin-dependent kinase (CDK) targets have opened a new level of signaling complexity by revealing signal processing routes encoded into disordered proteins. A model target, the CDK inhibitor Sic1, contains linear phosphorylation motifs, docking sites...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Venta, Rainis, Valk, Ervin, Örd, Mihkel, Košik, Oleg, Pääbo, Kaur, Maljavin, Artemi, Kivi, Rait, Faustova, Ilona, Shtaida, Nastassia, Lepiku, Martin, Möll, Kaidi, Doncic, Andreas, Kõivomägi, Mardo, Loog, Mart
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160111/
https://ncbi.nlm.nih.gov/pubmed/32296067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15685-z
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