Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions

Tuberculosis (TB) is the leading cause of death from a single infectious agent, requiring at least 6 months of multidrug treatment to achieve cure(1). However, the lack of reliable data on antimicrobial pharmacokinetics (PK) at infection sites hinders efforts to optimize antimicrobial dosing and sho...

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Publicado no:Nat Med
Main Authors: Ordonez, Alvaro A., Wang, Hechuan, Magombedze, Gesham, Ruiz-Bedoya, Camilo A., Srivastava, Shashikant, Chen, Allen, Tucker, Elizabeth W., Urbanowski, Michael E., Pieterse, Lisa, Cardozo, E. Fabian, Lodge, Martin A., Shah, Maunank R., Holt, Daniel P., Mathews, William B., Dannals, Robert F., Gobburu, Jogarao V. S., Peloquin, Charles A., Rowe, Steven P., Gumbo, Tawanda, Ivaturi, Vijay D., Jain, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160048/
https://ncbi.nlm.nih.gov/pubmed/32066976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0770-2
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