Polyunsaturated fatty acid analogues differentially affect cardiac Na(V), Ca(V), and K(V) channels through unique mechanisms

The cardiac ventricular action potential depends on several voltage-gated ion channels, including Na(V), Ca(V), and K(V) channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Bohannon, Briana M, de la Cruz, Alicia, Wu, Xiaoan, Jowais, Jessica J, Perez, Marta E, Dykxhoorn, Derek M, Liin, Sara I, Larsson, H Peter
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Structural Biology and Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159882/
https://ncbi.nlm.nih.gov/pubmed/32207683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51453
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