Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide

A GO‐to solution: A simple graphene oxide (GO)‐based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selec...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Jang, Hongje, Ryoo, Soo‐Ryoon, Kim, Young‐Kwan, Yoon, Soojin, Kim, Henna, Han, Sang Woo, Choi, Byong‐Seok, Kim, Dong‐Eun, Min, Dal‐Hee
Format: Artigo
Language:Inglês
Published: WILEY‐VCH Verlag 2013
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159783/
https://ncbi.nlm.nih.gov/pubmed/23355441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201209222
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