Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil

INTRODUCTION: The nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into its inactivated form, thioguanosine monophosphate. The frequency of alternative NUDT15 alleles, in particular those that cause a drastic loss...

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Publicat a:PLoS One
Autors principals: Rodrigues, Juliana Carla Gomes, de Souza, Tatiane Piedade, Pastana, Lucas Favacho, Ribeiro dos Santos, André Maurício, Fernandes, Marianne Rodrigues, Pinto, Pablo, Wanderley, Alayde Vieira, de Souza, Sandro José, Kroll, José Eduardo, Pereira, Adenilson Leão, Magalhães, Leandro, Mercês, Laís Reis das, Vidal, Amanda Ferreira, Vinasco-Sandoval, Tatiana, Cavalcante, Giovanna Chaves, Guerreiro, João Farias, de Assumpção, Paulo Pimentel, Ribeiro-dos-Santos, Ândrea, Santos, Sidney, dos Santos, Ney Pereira Carneiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159207/
https://ncbi.nlm.nih.gov/pubmed/32294118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231651
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