Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA

Influenza vaccine effectiveness varies annually due to the fast evolving seasonal influenza A(H3N2) strain and egg-derived mutations—both of which can cause a mismatch between the vaccine and circulating strains. To address these limitations, we have developed a hemagglutinin (HA)-based protein-dete...

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Pubblicato in:Vaccines (Basel)
Autori principali: Portnoff, Alyse D., Patel, Nita, Massare, Michael J., Zhou, Haixia, Tian, Jing-Hui, Zhou, Bin, Shinde, Vivek, Glenn, Gregory M., Smith, Gale
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157642/
https://ncbi.nlm.nih.gov/pubmed/32098409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines8010099
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