2753. Induction of Broadly Cross-Reactive Immune Responses Against A(H3N2) Airuses: Results of a Phase 2 Trial of a Novel Recombinant Hemagglutinin Saponin-Adjuvanted Nanoparticle Seasonal Influenza Vaccine

BACKGROUND: We developed a recombinant saponin-adjuvanted (Matrix-M1) quadrivalent hemagglutinin nanoparticle influenza vaccine (qNIV; NanoFlu) for older adults to address two impediments to efficacy of current, predominantly egg-derived, seasonal influenza vaccines: (1) limited protection against a...

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Published in:Open Forum Infect Dis
Main Authors: Shinde, Vivek, Cai, Rongman, Plested, Joyce S, Zhou, Bin, Zhou, Haixia, Zhu, Mingzhu, Wang, Nan, Cloney-Clark, Shane, Agrawal, Sapeck, Spindler, Michelle S, Patel, Nita, Massare, Michael, Smith, Gale, Thomas, D Nigel, Cho, Iksung, Fries, Louis F, Glenn, Gregory M
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809831/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.2430
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