RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections

BACKGROUND: The β-lactamase inhibitor relebactam can restore imipenem activity against imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam for treating imipenem-nonsusceptible infections. METHODS: Randomized, controlled, double-blind, phase 3 trial. Hospitalized patient...

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Bibliographic Details
Published in:Clin Infect Dis
Main Authors: Motsch, Johann, Murta de Oliveira, Cláudia, Stus, Viktor, Köksal, Iftihar, Lyulko, Olexiy, Boucher, Helen W, Kaye, Keith S, File, Thomas M, Brown, Michelle L, Khan, Ireen, Du, Jiejun, Joeng, Hee-Koung, Tipping, Robert W, Aggrey, Angela, Young, Katherine, Kartsonis, Nicholas A, Butterton, Joan R, Paschke, Amanda
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
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Articles and Commentaries
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156774/
https://ncbi.nlm.nih.gov/pubmed/31400759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz530
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