1951. Nephrotoxicity Associated With Imipenem/Cilastatin/Relebactam (IMI/REL) vs. Imipenem/Cilastatin Plus Colistin (IMI+CST) in Patients With Imipenem-Nonsusceptible (NS) Bacterial Infections

BACKGROUND: Nephrotoxicity is a common complication of CST-based therapy, limiting its use to treat carbapenem-resistant bacterial infections. REL is a novel β-lactamase inhibitor that restores imipenem activity against many imipenem-NS strains of Gram-negative pathogens. IMI/REL was shown to be as...

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Publicado no:Open Forum Infect Dis
Main Authors: Brown, Michelle, Motsch, Johann, Kaye, Keith, File, Thomas, Boucher, Helen W, Vendetti, Neika, Aggrey, Angela, Joeng, Hee-Koung, Tipping, Robert, Du, Jiejun, Depestel, Daryl D, Butterton, Joan, Kartsonis, Nicholas A, Paschke, Amanda
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252440/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1607
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