Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade

BACKGROUND: Cancer peptide vaccines show only marginal effects against cancers. Immune checkpoint inhibitors (ICIs) show significant curative effects in certain types of cancers, but the response rate is still limited. In this study, we aim to improve cancer peptide vaccination by targeting Ag pepti...

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Publicat a:Br J Cancer
Autors principals: Mizumoto, Yuki, Hemmi, Hiroaki, Katsuda, Masahiro, Miyazawa, Motoki, Kitahata, Yuji, Miyamoto, Atsushi, Nakamori, Mikihito, Ojima, Toshiyasu, Matsuda, Kenji, Nakamura, Masaki, Hayata, Keiji, Fukuda-Ohta, Yuri, Sugiyama, Masanaka, Ohta, Tomokazu, Orimo, Takashi, Okura, Soichiro, Sasaki, Izumi, Tamada, Koji, Yamaue, Hiroki, Kaisho, Tsuneyasu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156711/
https://ncbi.nlm.nih.gov/pubmed/32066911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0757-2
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