Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS) with heterogeneous pathophysiology. In its progressive course oligodendrocyte and neuroaxonal damage is sustained by compartmentalized inflammation due to glial dysregulation. Siponimod (BAF312),...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Colombo, Emanuela, Bassani, Claudia, De Angelis, Anthea, Ruffini, Francesca, Ottoboni, Linda, Comi, Giancarlo, Martino, Gianvito, Farina, Cinthia
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156595/
https://ncbi.nlm.nih.gov/pubmed/32322257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00635
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