An in vivo platform to select and evolve aggregation-resistant proteins

Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behav...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Ebo, Jessica S., Saunders, Janet C., Devine, Paul W. A., Gordon, Alice M., Warwick, Amy S., Schiffrin, Bob, Chin, Stacey E., England, Elizabeth, Button, James D., Lloyd, Christopher, Bond, Nicholas J., Ashcroft, Alison E., Radford, Sheena E., Lowe, David C., Brockwell, David J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156504/
https://ncbi.nlm.nih.gov/pubmed/32286330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15667-1
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares