Quantifying the heterogeneity of macromolecular machines by mass photometry

Sample purity is central to in vitro studies of protein function and regulation, and to the efficiency and success of structural studies using techniques such as x-ray crystallography and cryo-electron microscopy (cryo-EM). Here, we show that mass photometry (MP) can accurately characterize the hete...

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Vydáno v:Nat Commun
Hlavní autoři: Sonn-Segev, Adar, Belacic, Katarina, Bodrug, Tatyana, Young, Gavin, VanderLinden, Ryan T., Schulman, Brenda A., Schimpf, Johannes, Friedrich, Thorsten, Dip, Phat Vinh, Schwartz, Thomas U., Bauer, Benedikt, Peters, Jan-Michael, Struwe, Weston B., Benesch, Justin L. P., Brown, Nicholas G., Haselbach, David, Kukura, Philipp
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156492/
https://ncbi.nlm.nih.gov/pubmed/32286308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15642-w
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