Quantifying the heterogeneity of macromolecular machines by mass photometry

Sample purity is central to in vitro studies of protein function and regulation, and to the efficiency and success of structural studies using techniques such as x-ray crystallography and cryo-electron microscopy (cryo-EM). Here, we show that mass photometry (MP) can accurately characterize the hete...

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Published in:Nat Commun
Main Authors: Sonn-Segev, Adar, Belacic, Katarina, Bodrug, Tatyana, Young, Gavin, VanderLinden, Ryan T., Schulman, Brenda A., Schimpf, Johannes, Friedrich, Thorsten, Dip, Phat Vinh, Schwartz, Thomas U., Bauer, Benedikt, Peters, Jan-Michael, Struwe, Weston B., Benesch, Justin L. P., Brown, Nicholas G., Haselbach, David, Kukura, Philipp
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156492/
https://ncbi.nlm.nih.gov/pubmed/32286308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15642-w
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