Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Instead, the...

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Publicado no:Nat Commun
Main Authors: Daniels, Jay, Doukas, Peter G., Escala, Maria E. Martinez, Ringbloom, Kimberly G., Shih, David J. H., Yang, Jingyi, Tegtmeyer, Kyle, Park, Joonhee, Thomas, Jane J., Selli, Mehmet E., Altunbulakli, Can, Gowthaman, Ragul, Mo, Samuel H., Jothishankar, Balaji, Pease, David R., Pro, Barbara, Abdulla, Farah R., Shea, Christopher, Sahni, Nidhi, Gru, Alejandro A., Pierce, Brian G., Louissaint, Abner, Guitart, Joan, Choi, Jaehyuk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156460/
https://ncbi.nlm.nih.gov/pubmed/32286303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15572-7
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