Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

It is unclear why some tissues are refractory to the mitogenic effects of the oncogene Myc. Here we show that Myc activation induces rapid transcriptional responses followed by proliferation in some, but not all, organs. Despite such disparities in proliferative response, Myc is bound to DNA at open...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Bywater, Megan J., Burkhart, Deborah L., Straube, Jasmin, Sabò, Arianna, Pendino, Vera, Hudson, James E., Quaife-Ryan, Gregory A., Porrello, Enzo R., Rae, James, Parton, Robert G., Kress, Theresia R., Amati, Bruno, Littlewood, Trevor D., Evan, Gerard I., Wilson, Catherine H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156407/
https://ncbi.nlm.nih.gov/pubmed/32286286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15552-x
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky